abstract：:Mixture modeling within the context of pharmacokinetic (PK)/pharmacodynamic (PD) mixed effects modeling is a useful tool to explore a population for the presence of two or more subpopulations, not explained by evaluated covariates. At present, statistical tests for the existence of mixed populations have not been deve...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Frame B,Miller R,Lalonde RL

更新日期：2003-06-01 00:00:00

abstract：:The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective individualization of dr...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Durisová M,Dedík L

更新日期：2002-12-01 00:00:00

abstract：:Significant arterio-venous differences in nicotine concentrations have been observed during and after cigarette smoking, nicotine nasal spray, and intravenous nicotine administration. In this paper we describe a novel mathematical method for estimating arterial blood levels from venous blood level data. The model allo...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pitsiu M,Gries JM,Benowitz N,Gourlay SG,Verotta D

更新日期：2002-08-01 00:00:00

abstract：:The conventional convection-dispersion model is widely used to interrelate hepatic availability (F) and clearance (Cl) with the morphology and physiology of the liver and to predict effects such as changes in liver bloodflow on F and Cl. The extension of this model to include nonlinear kinetics and zonal heterogeneity...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Anissimov YG,Roberts MS

更新日期：2002-04-01 00:00:00

abstract：:Drugs that bind with high affinity and to a significant extent (relative to dose) to a pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear pharmacokinetic (PK) behavior. Processes such as receptor-mediated endocytosis may result in drug elimination. A general PK model for characteriz...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Mager DE,Jusko WJ

更新日期：2001-12-01 00:00:00

abstract：:The pharmacokinetics of cyclosporin (CsA) are unusual because of several heterogeneous features which include the presence of more than one conformer, considerable accumulation in erythrocytes and lipoproteins, extensive plasma protein binding, distribution into deep tissues, biliary secretion and hepatic clearance in...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Claret L,Iliadis A,Macheras P

更新日期：2001-10-01 00:00:00

abstract：:The pharmacokinetic-pharmacodynamic (PK-PD) relationship of the granulopoietic effects of Filgrastim in healthy volunteers was characterized via a population approach. Healthy male volunteers were enrolled into a four-way crossover clinical trial. Subjects received four single doses of Filgrastim (375 and 750 microgra...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Wang B,Ludden TM,Cheung EN,Schwab GG,Roskos LK

更新日期：2001-08-01 00:00:00

abstract：:We propose an efficient algorithm for screening covariates in population model building using Wald's approximation to the likelihood ratio test (LRT) statistic in conjunction with Schwarz's Bayesian criterion. The algorithm can be applied to a full model fit of k covariate parameters to calculate the approximate LRT f...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kowalski KG,Hutmacher MM

更新日期：2001-06-01 00:00:00

abstract：:The purpose of this study was to evaluate whether mixed effects modeling (MEM) performs better than either noncompartmental or compartmental naïve pooled data (NPD) analysis for the interpretation of single sample per subject pharmacokinetic (PK) data. Using PK parameters determined during a toxicokinetic study in rat...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hing JP,Woolfrey SG,Greenslade D,Wright PM

更新日期：2001-04-01 00:00:00